NAD+ injections, prescribed and delivered to you
NAD+ is the cellular energy molecule that declines with age. The IV-clinic version of NAD+ runs $300-$800 per session and requires you to sit for hours. The at-home injectable version, when it is clinically appropriate, does the same job for a fraction of the cost and time.
Why NAD+ matters
NAD+ levels fall steadily across the lifespan. By age 60, most people have roughly half the NAD+ in their tissues compared to age 20.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that appears in essentially every cell of the body. It is required for hundreds of metabolic reactions, including the work of sirtuins (the SIRT1-SIRT7 family of longevity-relevant proteins), PARPs (DNA repair enzymes), and CD38 (an immune-cell enzyme that, somewhat counterproductively, also consumes NAD+). When NAD+ levels are good, cellular energy production runs smoothly, DNA damage gets repaired, and the longevity-relevant pathways have the substrate they need to do their work.
As we age, NAD+ levels decline through a combination of reduced synthesis and increased consumption — particularly via CD38, which rises with age and chronic inflammation. This decline is one of the more universal biochemical markers of aging, and supporting NAD+ levels through dietary precursors (NR, NMN), IV NAD+, and now injectable NAD+ has become a major focus of practical longevity care.
The IV-clinic version of NAD+ therapy has been around for over a decade. It works but is impractical for most people — single sessions take 2-4 hours and cost hundreds of dollars. The injectable form is dose-matched, far cheaper, and self-administered after a single training visit.
Who NAD+ injections might help
Persistent fatigue
Energy that doesn't recover with sleep, particularly post-viral or in mid-life decline.
Cognitive demands
Members in cognitively demanding professions report sharper focus during heavy workloads.
Recovery from training
Athletes report faster recovery and better tolerance of high training volumes.
Active longevity protocol
NAD+ pairs well with rapamycin, metformin, methylene blue, and other longevity interventions.
How HealifyNow makes it simple
From your first message to your medication arriving at your door — clinician-guided, every step.
Schedule your free visit
A care team member meets with you to understand your goals, medical history, and treatment preferences. The first visit is no-cost and no-commitment — we want you to be confident before moving forward.
Meet your licensed clinician
Connect by secure video or phone with a U.S.-licensed physician or nurse practitioner who reviews your full picture — labs, prior treatments, current medications, and lifestyle — and decides what is clinically appropriate.
Receive your prescription if appropriate
If your clinician determines treatment is right for you, they issue a prescription that goes to a licensed U.S. pharmacy. We coordinate discreet shipping, or you can fill it locally. Follow-up visits are built in.
What NAD+ actually does in cells
Mitochondrial energy production. Every step of the Krebs cycle and electron transport chain depends on the NAD+/NADH ratio. Higher NAD+ availability means more efficient ATP production, particularly in tissues with high energy demand (brain, heart, muscle).
Sirtuin activation. Sirtuins are NAD+-dependent enzymes that play a major role in longevity pathways — DNA repair, mitochondrial biogenesis, stress resistance, inflammation control. Without enough NAD+, sirtuins cannot function. Many of the "live longer" effects associated with caloric restriction route through sirtuin activation.
DNA repair via PARPs. PARP enzymes use NAD+ to repair DNA damage. As we accumulate damage with age, NAD+ gets consumed at higher rates — which is itself one reason NAD+ levels fall.
Circadian regulation. The NAD+/NADH ratio drives the circadian clock at the cellular level. Disrupted NAD+ levels are tied to disrupted sleep architecture and metabolic dysregulation.
Neuroprotection. Brain tissue is particularly NAD+-dependent. Animal studies and emerging human studies show neuroprotective effects from NAD+ restoration, particularly in cognitive aging.
Safety information
Your clinician will review every relevant detail with you. Here are the most important points to know up front.
Generally well-tolerated
Most members tolerate subcutaneous NAD+ well. The most common side effects are mild injection-site irritation and brief flushing.
Flushing during IV use
IV NAD+ causes a flushing or chest-tightness sensation if pushed too fast. The injectable subcutaneous form largely avoids this because absorption is gradual.
No major drug interactions
NAD+ does not have known significant prescription drug interactions, but your clinician will still review your full medication list.
Not for active cancer treatment
NAD+ supplementation during active cancer therapy is debated. We do not prescribe to members in active cancer treatment without coordination with their oncologist.
All medications must be prescribed by a licensed provider based on medical necessity. Treatment is not suitable for everyone. Results may vary.
How to use injectable NAD+
After your clinical evaluation, your prescription ships from a licensed U.S. compounding pharmacy. You receive vials of pharmaceutical-grade NAD+, syringes, and clear written instructions. Members typically inject subcutaneously (the same technique as semaglutide) into the abdomen or thigh.
Typical dosing for longevity use is 50-100 mg per injection, given 1-3 times per week, in cycles. Some members do daily for two weeks then take a break; some stay on 2-3 times per week ongoing. Your clinician will personalize based on your goals and how you respond.
Most members notice subjective effects within 2-3 weeks of consistent dosing — typically better mental clarity, improved energy, and faster recovery from physical or cognitive load. The objective benefits (DNA repair, mitochondrial function) accumulate quietly over months.
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Patients served across the U.S.
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Member satisfaction with care team
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Average review rating
3 days
From visit to medication shipment
Why patients choose HealifyNow
We built HealifyNow because telehealth done badly is everywhere — and telehealth done right still feels rare. Here is what makes us different.
Easy Online Process
No waiting rooms, no faxed forms, no insurance hoops. Quick consults, simple intake, prescriptions handled digitally.
U.S.-Licensed Clinicians
Real physicians, nurse practitioners, and specialists licensed in your state. Not chatbots, not offshore call centers.
Discreet Home Delivery
Medications ship from licensed U.S. pharmacies in plain packaging. Most orders arrive in 2-5 business days.
Support That Answers
Reach a real human seven days a week. Most messages get a clinical reply within a few hours, not days.
Real U.S.-licensed clinicians
Every prescription on HealifyNow is reviewed and authorized by an independently licensed physician or nurse practitioner. No bots, no shortcuts.
Board-Certified Physician
Board-certified internal medicine physicians on our care team provide evidence-based evaluations for weight management, metabolic health, and longevity care. Every patient is reviewed individually with treatment recommendations based on clinical need.
Family Nurse Practitioner
Family nurse practitioners with 10+ years of telehealth experience handle hormone optimization, perimenopause care, and wellness protocols. Care is patient-centered and grounded in current evidence.
Board-Certified Physician
Endocrinology-trained physicians review every member with insulin resistance, PCOS, thyroid issues, or complex metabolic patterns. Treatment decisions are based on labs, history, and your goals.
Licensed Mental Health Clinician
Licensed psychologists, LCSWs, LMFTs, and psychiatric NPs across all 50 states handle ESA and PSD evaluations alongside anxiety and depression care. Real evaluation, never rubber-stamping.
What members are saying
Real people, real results. Names and details published with permission.
"Twice-weekly injection at home, takes 30 seconds. Same therapeutic dose as the IV clinics for a tenth the cost. I'm baffled this isn't more widely available."
"Energy returned about three weeks in. I'd done the IV route a few times — this is actually more sustainable because I can stay consistent."
"Doing a hard sport at 47 — recovery between sessions was the issue. Adding NAD+ shifted that meaningfully. My HRV trended up over two months."
Frequently asked questions
HealifyNow makes it easy to move forward with confidence. Here are the answers to what people ask us most.
How does injectable NAD+ compare to NAD+ IV therapy?
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Same active molecule, different delivery. Subcutaneous injection releases more slowly than IV, which actually avoids most of the flushing/chest-tightness that IV NAD+ causes when pushed quickly. The injectable form is far cheaper and far more convenient. Pharmacokinetically, repeated subcutaneous dosing produces similar tissue exposure to occasional high-dose IV.
How is this different from NMN or NR supplements?
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NMN and NR are oral precursors — your body converts them to NAD+. They work, but the conversion is partial and some of the dose is lost. Injectable NAD+ bypasses the conversion. For people who haven't responded to oral precursors, injection often produces a clearer effect.
Will my insurance cover NAD+ injections?
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No. NAD+ injections for longevity use are paid out of pocket. The HealifyNow program is priced to be substantially cheaper than IV clinic alternatives.
Can I do injections myself, or do I need to come to a clinic?
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Self-injection at home is the norm. You'll get clear written instructions and a one-on-one training video visit before your first injection if you want one. The technique is the same as semaglutide self-injection.
What dose is right for me?
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Typical doses range from 25 mg to 100 mg per injection, given 1-3 times weekly. Your clinician will start you conservatively and adjust based on response and goals.
How long do members typically stay on NAD+?
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There is no fixed duration. Many use it ongoing as part of a longevity protocol. Some cycle on and off (six weeks on, two weeks off, for example). Discontinuation does not cause withdrawal; the levels gradually return to baseline.
Is there evidence for cognitive improvement?
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Animal evidence is strong, particularly for protection against neurodegenerative pathology. Human evidence is emerging — small trials show improvements in age-related cognitive markers. Member-reported cognitive effects are common; objective evidence is still being built.
Can I take NAD+ with semaglutide or tirzepatide?
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Yes. These are complementary protocols — GLP-1 medications address metabolism and weight, NAD+ addresses cellular energy and longevity pathways. Many members take both.
Restore your cellular energy currency.
Book a free consultation to see if NAD+ injection therapy fits your goals — and skip the $500 IV clinic visits.