
- Longevity
- Weight management
- Metabolic health
Dr. Benjamin H. Krasne, M.D.
A board-certified physician who brings a rigorous, pharmacology-driven lens to longevity medicine and weight management.
NAD+ is the cellular energy molecule that declines with age. The IV-clinic version of NAD+ runs $300-$800 per session and requires you to sit for hours. The at-home injectable version, when it is clinically appropriate, does the same job for a fraction of the cost and time.
NAD+ levels fall steadily across the lifespan. By age 60, most people have roughly half the NAD+ in their tissues compared to age 20.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that appears in essentially every cell of the body. It is required for hundreds of metabolic reactions, including the work of sirtuins (the SIRT1-SIRT7 family of longevity-relevant proteins), PARPs (DNA repair enzymes), and CD38 (an immune-cell enzyme that, somewhat counterproductively, also consumes NAD+). When NAD+ levels are good, cellular energy production runs smoothly, DNA damage gets repaired, and the longevity-relevant pathways have the substrate they need to do their work.
As we age, NAD+ levels decline through a combination of reduced synthesis and increased consumption — particularly via CD38, which rises with age and chronic inflammation. This decline is one of the more universal biochemical markers of aging, and supporting NAD+ levels through dietary precursors (NR, NMN), IV NAD+, and now injectable NAD+ has become a major focus of practical longevity care.
The IV-clinic version of NAD+ therapy has been around for over a decade. It works but is impractical for most people — single sessions take 2-4 hours and cost hundreds of dollars. The injectable form is dose-matched, far cheaper, and self-administered after a single training visit.
Energy that doesn't recover with sleep, particularly post-viral or in mid-life decline.
Members in cognitively demanding professions report sharper focus during heavy workloads.
Athletes report faster recovery and better tolerance of high training volumes.
NAD+ pairs well with rapamycin, metformin, methylene blue, and other longevity interventions.
From your first message to your medication arriving at your door — clinician-guided, every step.
A care team member meets with you to understand your goals, medical history, and treatment preferences. The first visit is no-cost and no-commitment — we want you to be confident before moving forward.
Connect by secure video or phone with a U.S.-licensed physician or nurse practitioner who reviews your full picture — labs, prior treatments, current medications, and lifestyle — and decides what is clinically appropriate.
If your clinician determines treatment is right for you, they issue a prescription that goes to a licensed U.S. pharmacy. We coordinate discreet shipping, or you can fill it locally. Follow-up visits are built in.
Mitochondrial energy production. Every step of the Krebs cycle and electron transport chain depends on the NAD+/NADH ratio. Higher NAD+ availability means more efficient ATP production, particularly in tissues with high energy demand (brain, heart, muscle).
Sirtuin activation. Sirtuins are NAD+-dependent enzymes that play a major role in longevity pathways — DNA repair, mitochondrial biogenesis, stress resistance, inflammation control. Without enough NAD+, sirtuins cannot function. Many of the "live longer" effects associated with caloric restriction route through sirtuin activation.
DNA repair via PARPs. PARP enzymes use NAD+ to repair DNA damage. As we accumulate damage with age, NAD+ gets consumed at higher rates — which is itself one reason NAD+ levels fall.
Circadian regulation. The NAD+/NADH ratio drives the circadian clock at the cellular level. Disrupted NAD+ levels are tied to disrupted sleep architecture and metabolic dysregulation.
Neuroprotection. Brain tissue is particularly NAD+-dependent. Animal studies and emerging human studies show neuroprotective effects from NAD+ restoration, particularly in cognitive aging.
Your clinician will review every relevant detail with you. Here are the most important points to know up front.
Most members tolerate subcutaneous NAD+ well. The most common side effects are mild injection-site irritation and brief flushing.
IV NAD+ causes a flushing or chest-tightness sensation if pushed too fast. The injectable subcutaneous form largely avoids this because absorption is gradual.
NAD+ does not have known significant prescription drug interactions, but your clinician will still review your full medication list.
NAD+ supplementation during active cancer therapy is debated. We do not prescribe to members in active cancer treatment without coordination with their oncologist.
All medications must be prescribed by a licensed provider based on medical necessity. Treatment is not suitable for everyone. Results may vary.
After your clinical evaluation, your prescription ships from a licensed U.S. compounding pharmacy. You receive vials of pharmaceutical-grade NAD+, syringes, and clear written instructions. Members typically inject subcutaneously (the same technique as semaglutide) into the abdomen or thigh.
Typical dosing for longevity use is 50-100 mg per injection, given 1-3 times per week, in cycles. Some members do daily for two weeks then take a break; some stay on 2-3 times per week ongoing. Your clinician will personalize based on your goals and how you respond.
Most members notice subjective effects within 2-3 weeks of consistent dosing — typically better mental clarity, improved energy, and faster recovery from physical or cognitive load. The objective benefits (DNA repair, mitochondrial function) accumulate quietly over months.
Get a fast read on whether this is worth a deeper conversation.
Patients served across the U.S.
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We built HealifyNow because telehealth done badly is everywhere — and telehealth done right still feels rare. Here is what makes us different.
No waiting rooms, no faxed forms, no insurance hoops. Quick consults, simple intake, prescriptions handled digitally.
Real physicians, nurse practitioners, and specialists with active licenses. Not chatbots, not offshore call centers.
Medications ship from licensed U.S. pharmacies in plain packaging. Most orders arrive in 2-5 business days.
Reach a real human seven days a week. Most messages get a clinical reply within a few hours, not days.
HealifyNow prescriptions are reviewed and authorized by independently licensed physicians — real doctors with real credentials from top medical institutions in the United States.

A board-certified physician who brings a rigorous, pharmacology-driven lens to longevity medicine and weight management.

A Columbia-trained physician and former collegiate athlete focused on metabolic function, body composition, and healthspan.

A board-certified OB-GYN and ACOG Fellow with more than four decades of experience in women's health.
Real people, real results. Names and details published with permission.
"Twice-weekly injection at home, takes 30 seconds. Same therapeutic dose as the IV clinics for a tenth the cost. I'm baffled this isn't more widely available."
"Energy returned about three weeks in. I'd done the IV route a few times — this is actually more sustainable because I can stay consistent."
"Doing a hard sport at 47 — recovery between sessions was the issue. Adding NAD+ shifted that meaningfully. My HRV trended up over two months."
HealifyNow makes it easy to move forward with confidence. Here are the answers to what people ask us most.
Same active molecule, different delivery. Subcutaneous injection releases more slowly than IV, which actually avoids most of the flushing/chest-tightness that IV NAD+ causes when pushed quickly. The injectable form is far cheaper and far more convenient. Pharmacokinetically, repeated subcutaneous dosing produces similar tissue exposure to occasional high-dose IV.
NMN and NR are oral precursors — your body converts them to NAD+. They work, but the conversion is partial and some of the dose is lost. Injectable NAD+ bypasses the conversion. For people who haven't responded to oral precursors, injection often produces a clearer effect.
No. NAD+ injections for longevity use are paid out of pocket. The HealifyNow program is priced to be substantially cheaper than IV clinic alternatives.
Self-injection at home is the norm. You'll get clear written instructions and a one-on-one training call by phone or video before your first injection if you want one. The technique is the same as semaglutide self-injection.
Typical doses range from 25 mg to 100 mg per injection, given 1-3 times weekly. Your clinician will start you conservatively and adjust based on response and goals.
There is no fixed duration. Many use it ongoing as part of a longevity protocol. Some cycle on and off (six weeks on, two weeks off, for example). Discontinuation does not cause withdrawal; the levels gradually return to baseline.
Animal evidence is strong, particularly for protection against neurodegenerative pathology. Human evidence is emerging — small trials show improvements in age-related cognitive markers. Member-reported cognitive effects are common; objective evidence is still being built.
Yes. These are complementary protocols — GLP-1 medications address metabolism and weight, NAD+ addresses cellular energy and longevity pathways. Many members take both.
Book a free consultation, answer a short health questionnaire, then meet a licensed clinician by secure video or phone. If NAD+ injections is medically appropriate, your clinician sends the prescription to a licensed U.S. pharmacy and it ships to your door.
Yes. Telehealth prescribing is legal when a licensed clinician evaluates you first. NAD+ injections is only prescribed when it's clinically appropriate, and it's filled by a licensed U.S. pharmacy.
NAD+ injections pricing is $199/month. Your first consultation is free, you don't need insurance, and your clinician confirms the exact cost before anything is prescribed.
Many members meet a clinician within a few days of booking. If NAD+ injections are prescribed, it ships in discreet packaging and most orders arrive within 2 to 5 business days.
Your clinician reviews your medical history, current medications, past treatments and goals by secure video or phone, explains the benefits and side effects, and agrees a plan with you. Labs may be ordered if needed.
Sometimes. Depending on your history, your clinician may ask for recent results or order a lab panel before prescribing NAD+ injections. Lab testing can be arranged at draw sites nationwide.
Your care team explains how to self-inject, including dosing, injection sites and safe sharps disposal, and you can message them with questions.
Book a free consultation to see if NAD+ injection therapy fits your goals — and skip the $500 IV clinic visits.