Does Semaglutide Cause Fatigue?

Does Semaglutide Cause Fatigue?

Recently championed as an effective solution to weight loss management, there are concerns that semaglutide can induce fatigue. The medication is designed to inhibit your appetite by regulating blood sugar levels. It does this by slowing down the production of hormones like ghrelin that trigger hunger. As a result, your body will experience a calorific deficit translating into low energy levels. This reduction can cause you to feel tired more quickly and easily.

In this article, you’ll learn why you experience fatigue on semaglutide. It will also highlight factors that may influence how tired you get while on the Semaglutide Prescription.

Factors That Influence How Tired You Feel on Semaglutide

You need to account for an adjustment period that your body may require before embarking on semaglutide treatment. Like in most situations, your body will need to acclimatize and get used to the drug. Fatigue can occur during this transition period but will likely wane off with continued use. Listed below are some factors that can influence how tired you feel during semaglutide therapy:

Prescription Dosage Plan

Your treatment plan can affect how tired you feel. Being the active ingredient in most weight-related drugs, doctors can advise you to take semaglutide weekly through self-administered injections. Wegovy and Ozempic are best suited for this. You can also undertake semaglutide therapy daily through the Rybelsus oral treatment plan. Most clinical trial results suggest that patients taking semaglutide injections are more prone to fatigue.

Workout Routine Disruption

Understandably, your fitness regimen can change when you’re under semaglutide therapy. This can be a result of the medicine’s side effects. Reduced activity can cause you to feel demotivated and sluggish triggering feelings of fatigue.

Prescription Quantity

If you’re on a higher dosage of semaglutide, you’re likely to feel more tired. Wegovy carries the maximum dosage amount of 2.4 mg for semaglutide therapy. As a result, you’ll experience more fatigue when on this treatment plan. Fortunately, there are low-dosage options. You should start with lower amounts and scale the quantity as you go to avoid adverse side effects.

Digestive Tract Issues

You can experience several side effects when under semaglutide therapy. Diarrhea, nausea, and vomiting are common issues. This can irritate your digestive system, cause dehydration, and negatively affect your sleep patterns. The resultant effect can result in a dip in your energy levels triggering fatigue.


Granted, suffering from long-term conditions like diabetes can trigger anxiety as it can be overbearing on the patient. However, research studies also suggest that semaglutide can increase anxiety and trigger depressive episodes. This can affect your sleep health which in turn affects your energy levels causing you to feel tired quickly.

Semaglutide Treatment Fatigue Management Tips

Semaglutide therapy can heavily impact your overall wellness. However, there are steps you can take to manage the resultant fatigue. Here’s what you can do to manage the side effect:

Consult a Health Practitioner

If you’re undergoing semaglutide therapy and experiencing fatigue, you need your give yourself grace. The side effect is more common than it’s talked about. Speak to a certified medical practitioner to help you find clarity and support. This will help alleviate feelings of anxiety which can trigger tiredness. Your doctor can also adjust the semaglutide treatment plan where necessary to help improve your quality of life.

Scale Dosage Slowly

Semaglutide takes a few weeks to present any notable changes in your body regarding weight loss. This means that the active pharmaceutical compound needs some time to be effectively assimilated into your system. To avoid compounding the drug’s side effects, it’s best to gradually increase its dosage over time allowing your body time for acclimatization.

Incorporate Workouts

You’ll need to embrace workouts and include them in your lifestyle. Apart from helping you to maximize the potential benefits of semaglutide therapy, regular exercise will help increase your energy levels. This is because physical activity helps enhance the production of mitochondria which is responsible for increasing energy supply within your body.


You need to drink enough water during semaglutide treatment. Given that some of the drug’s common side effects include vomiting and diarrhea, your body will lose substantial amounts of water. This can affect oxygen supply and blood flow to your brain resulting in feelings of tiredness. Hydrating will help you to counter this side effect.

Eat Well

You need to maintain a balanced diet when on semaglutide. Given that the medication impacts your blood sugar and glucose levels, great nutrition helps enhance your overall wellness. Adequate protein and iron intake is beneficial, especially for women. Include fiber and tool softener to improve your bowel regimen. This helps to reduce fatigue by improving the overall health of the digestive tract ensuring that all by-products are excreted regularly. You can consult a nutrition expert to help you gain optimal benefits when undergoing semaglutide therapy.

Prioritize Rest

Now that you’ve identified fatigue as one of the side effects of semaglutide treatment, you need to allocate enough time to rest. Try and create a sleeping pattern that allows you to consistently go early to bed. Ensure your sleeping environment is calm and peaceful. You should get at least seven hours of sleep each night. This can help you to manage the side effects better.

Check Your Drug Combinations

Some drug interactions aren’t safe during semaglutide therapy. If you feel that the fatigue isn’t diminishing over time, it’s best to speak to your doctor and discuss your medication list. Ensure open communication by highlighting all medications you’re currently taking. Your doctor will guide you on which medicine you should cut off or review the medicine timing to help mitigate the side effects.

Navigating Semaglutide Therapy and the Resulting Fatigue

Weight loss management is a deeply personal journey that requires a comprehensive approach to succeed. You may need to incorporate diet changes and workout routines into your plan. Understandably, fatigue is a cause of concern for many patients. Fortunately, this issue typically resolves on its own as your body adapts to semaglutide therapy.

Remember to seek the guidance of a healthcare practitioner for guidance and support. They can accurately identify underlying conditions and advise appropriately. Embark on your weight loss transformation with Healify Now. Our Semaglutide program runs at $299 for 30 days! Personalized care is essential when under semaglutide therapy to ensure you enjoy optimal benefits.

Must Read: Can You Drink Alcohol While Taking Semaglutide?

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